Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

Published:2012-07-27 Issue:19 Volume:55 Page:8211-8224
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Díaz José Luis¹,Cuberes Rosa¹,Berrocal Joana¹,Contijoch Montserrat¹,Christmann Ute¹,Fernández Ariadna¹,Port Adriana¹,Holenz Jörg¹,Buschmann Helmut¹,Laggner Christian²,Serafini Maria Teresa¹,Burgueño Javier¹,Zamanillo Daniel¹,Merlos Manuel¹,Vela José Miguel¹,Almansa Carmen¹

Affiliation:

1. Drug Discovery and Preclinical Development, Esteve, Av. Mare de Déu de Montserrat, 221, 08041, Barcelona, Spain

2. Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3007323

Reference50 articles.

1. A proposal for the classification of sigma binding sites

2. Purification, molecular cloning, and expression of the mammalian sigma1-binding site.