Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders-Reference-Cited by-同舟云学术

Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders

Published:2012-07-25 Issue:21 Volume:55 Page:9045-9054
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Verhoest Patrick R.¹,Fonseca Kari R.¹,Hou Xinjun¹,Proulx-LaFrance Caroline¹,Corman Michael¹,Helal Christopher J.¹,Claffey Michelle M.¹,Tuttle Jamison B.¹,Coffman Karen J.¹,Liu Shenpinq¹,Nelson Frederick¹,Kleiman Robin J.¹,Menniti Frank S.¹,Schmidt Christopher J.¹,Vanase-Frawley Michelle¹,Liras Spiros¹

Affiliation:

1. Neuroscience Medicinal Chemistry, Pfizer World Wide Research and Development, 700 Main Street, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3007799

Reference30 articles.

1. Phosphodiesterase Inhibitors as Potential Cognition Enhancing Agents

2. Phosphodiesterase 5 Inhibitors for Erectile Dysfunction

Cited by 76 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The therapeutic potential of phosphodiesterase 9 (PDE9) inhibitors: a patent review (2018-present);Expert Opinion on Therapeutic Patents;2024-07-09

2. Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases;Medicinal Research Reviews;2024-01-27

3. Visible light-induced organo-photocatalyzed route to synthesize substituted pyrazoles;Organic & Biomolecular Chemistry;2024

4. An overview of phosphodiesterase 9 inhibitors: Insights from skeletal structure, pharmacophores, and therapeutic potential;European Journal of Medicinal Chemistry;2023-11

5. Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model;ACS Chemical Neuroscience;2023-09-19