Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity-Reference-Cited by-同舟云学术

Novel Cambinol Analogs as Sirtuin Inhibitors: Synthesis, Biological Evaluation, and Rationalization of Activity

Published:2009-04-01 Issue:9 Volume:52 Page:2673-2682
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Medda Federico¹,Russell Rupert J. M.¹,Higgins Maureen¹,McCarthy Anna R.¹,Campbell Johanna¹,Slawin Alexandra M. Z.¹,Lane David P.¹,Lain Sonia¹,Westwood Nicholas J.¹

Affiliation:

1. School of Chemistry and Centre for Biomolecular Sciences and School of Biology and Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife, KY16 9ST, Scotland, U.K., and Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8014298

Reference33 articles.

1. p53 in health and disease

2. Pilot screening programme for small molecule activators of p53

3. Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

4. hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

5. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

Cited by 121 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Activation and inhibition of sirtuins: From bench to bedside;Medicinal Research Reviews;2024-08-31

2. Ubiquitous Role of Phosphine‐Based Water‐Soluble Ligand in Promoting Catalytic Reactions in Water;The Chemical Record;2024-08-20

3. Research progress on Sirtuins (SIRTs) family modulators;Biomedicine & Pharmacotherapy;2024-05

4. Targeting Sirtuin 1 for therapeutic potential: Drug repurposing approach integrating docking and molecular dynamics simulations;PLOS ONE;2023-12-20

5. Structure, functions, and recent advances in the development of SIRT2 inhibitors;Pharmaceutical Science Advances;2023-12