Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents-Reference-Cited by-同舟云学术

Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Published:2009-07-16 Issue:15 Volume:52 Page:4892-4902
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gangjee Aleem¹,Li Wei¹,Kisliuk Roy L.²,Cody Vivian³,Pace Jim³,Piraino Jennifer³,Makin Jennifer³

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282

2. Department of Biochemistry, School of Medicine, Tufts University, Boston, Massachusetts 02111

3. Hauptman-Woodward Medical Research Institute, Inc., 700 Ellicott Street, Buffalo, New York 14203

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900490a

Reference41 articles.

1. Towards Species-specific Antifolates

2. Dihydrofolate reductase inhibitors as antibacterial agents

3. Novel Chemical Strategies for Thymidylate Synthase Inhibition