Identification of Oxidation Sites and Covalent Cross-Links in Metal Catalyzed Oxidized Interferon Beta-1a: Potential Implications for Protein Aggregation and Immunogenicity-Reference-Cited by-同舟云学术

Identification of Oxidation Sites and Covalent Cross-Links in Metal Catalyzed Oxidized Interferon Beta-1a: Potential Implications for Protein Aggregation and Immunogenicity

Published:2013-05-02 Issue:6 Volume:10 Page:2311-2322
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Torosantucci Riccardo¹²,Sharov Victor S.²,van Beers Miranda³,Brinks Vera⁴,Schöneich Christian²,Jiskoot Wim¹

Affiliation:

1. Division of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands

2. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, United States

3. Bioprocessing Technology Institute, Agency for Science Technology and Research (A*STAR), Singapore

4. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CA Utrecht, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp300665u

Reference51 articles.

1. Direct Evidence That IFN-β Functions as a Tumor-Suppressor Protein

2. Gelatinase B/matrix metalloproteinase‐9 cleaves interferon‐β and is a target for immunotherapy

3. Comparative study of the asparagine-linked sugar chains of natural human interferon-beta 1 and recombinant human interferon-beta 1 produced by three different mammalian cells.

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