Probes for Narcotic Receptor Mediated Phenomena. 26. Synthesis and Biological Evaluation of Diarylmethylpiperazines and Diarylmethylpiperidines as Novel, Nonpeptidic δ Opioid Receptor Ligands-Reference-Cited by-同舟云学术

Probes for Narcotic Receptor Mediated Phenomena. 26. Synthesis and Biological Evaluation of Diarylmethylpiperazines and Diarylmethylpiperidines as Novel, Nonpeptidic δ Opioid Receptor Ligands

Published:1999-12-01 Issue:26 Volume:42 Page:5455-5463
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Xiaoyan¹,Rice Kenner C.¹,Calderon Silvia N.¹,Kayakiri Hiroshi¹,Smith Larren¹,Coop Andrew¹,Jacobson Arthur E.¹,Rothman Richard B.¹,Davis Peg¹,Dersch Christina M.¹,Porreca Frank¹

Affiliation:

1. Laboratory of Medicinal Chemistry, Building 8, Room B1-23, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, and Clinical Psychopharmacology Section, National Institute on Drug Abuse, Addiction Research Center, Baltimore, Maryland 21224, and Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona 85724

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9903895

Reference40 articles.

1. Probes for Narcotic Receptor Mediated Phenomena. 23. Synthesis, Opioid Receptor Binding, and Bioassay of the Highly Selective δ Agonist (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and Related Novel Nonpeptide δ Opioid Receptor Ligands

2. Stereospecific Binding of the Potent Narcotic Analgesic [3H]Etorphine to Rat-Brain Homogenate

3. Endogenous opioid peptides: multiple agonists and receptors

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