Design, Synthesis, Radiolabeling, and in Vivo Evaluation of Carbon-11 Labeled N-[2-[4-(3-Cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a Potential Positron Emission Tomography Tracer for the Dopamine D4 Receptors-Reference-Cited by-同舟云学术

Design, Synthesis, Radiolabeling, and in Vivo Evaluation of Carbon-11 Labeled N-[2-[4-(3-Cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a Potential Positron Emission Tomography Tracer for the Dopamine D4 Receptors

Published:2010-09-27 Issue:20 Volume:53 Page:7344-7355
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lacivita Enza¹,De Giorgio Paola¹,Lee Irene T.²,Rodeheaver Sean I.²,Weiss Bryan A.²,Fracasso Claudia³,Caccia Silvio³,Berardi Francesco¹,Perrone Roberto¹,Zhang Ming-Rong⁴,Maeda Jun⁴,Higuchi Makoto⁴,Suhara Tetsuya⁴,Schetz John A.²⁵⁶⁷,Leopoldo Marcello¹

Affiliation:

1. Dipartimento Farmaco-Chimico, Università degli Studi di Bari “A. Moro”, Via Orabona, 4, 70125, Bari, Italy

2. Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107-2699, United States

3. Istituto di Ricerche Farmacologiche “Mario Negri”, Via La Masa 19, 20156 Milan, Italy

4. Molecular Imaging Center, National Institute of Radiological Sciences, 9-1, 4-Chome, Anagawa, Inage-ku, 263-8555, Chiba, Japan

5. Department of Psychiatry, Texas College of Osteopathic Medicine, Fort Worth, Texas 76107, United States

6. Department of Health Management and Policy, School of Public Health, Fort Worth, Texas 76107, United States

7. Department of Biology, University of Texas at Arlington, Arlington, Texas 76109, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100925m

Reference67 articles.

1. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

2. Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications

3. The Effects of a Selective D4 Dopamine Receptor Antagonist (L-745,870) in Acutely Psychotic Inpatients With Schizophrenia

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