Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids-Reference-Cited by-同舟云学术

Three Mutations Convert the Selectivity of a Protein Sensor from Nicotinic Agonists to S-Methadone for Use in Cells, Organelles, and Biofluids

Published:2022-04-21 Issue:19 Volume:144 Page:8480-8486
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Muthusamy Anand K.¹²^ORCID,Kim Charlene H.¹,Virgil Scott C.²,Knox Hailey J.²,Marvin Jonathan S.³^ORCID,Nichols Aaron L.¹,Cohen Bruce N.¹,Dougherty Dennis A.²^ORCID,Looger Loren L.⁴,Lester Henry A.¹

Affiliation:

1. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91106, United States

2. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91106, United States

3. Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia 20147, United States

4. Howard Hughes Medical Institute, University of California, San Diego, San Diego, California 92093, United States

Funder

Howard Hughes Medical Institute

National Institute of Neurological Disorders and Stroke

Tobacco-Related Disease Research Program

National Institute on Drug Abuse

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c02323

Reference34 articles.

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