Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion-Reference-Cited by-同舟云学术

Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion

Published:2022-11-18 Issue:48 Volume:144 Page:21972-21979
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Gibaut Quentin M. R.¹,Akahori Yoshihiro¹,Bush Jessica A.¹,Taghavi Amirhossein¹,Tanaka Toru¹,Aikawa Haruo¹^ORCID,Ryan Lucas S.¹,Paegel Brian M.¹²^ORCID,Disney Matthew D.¹^ORCID

Affiliation:

1. Department of Chemistry, UF Scripps Biomedical Research and The Scripps Research Institute, Jupiter, Florida 33458, United States

2. Department of Chemistry and Pharmaceutical Sciences, University of California, Irvine, California 92617, United States

Funder

National Institute of Neurological Disorders and Stroke

U.S. Department of Defense

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c08883

Reference55 articles.

1. Structural imprints in vivo decode RNA regulatory mechanisms

2. Targeting RNA with Small Molecules

3. Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

4. Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan

5. High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections

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