Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents

Author:

Istrate Alena1,Geeson Michael B.1ORCID,Navo Claudio D.2ORCID,Sousa Barbara B.3,Marques Marta C.3,Taylor Ross J.1,Journeaux Toby1ORCID,Oehler Sebastian R.4,Mortensen Michael R.4,Deery Michael J.5,Bond Andrew D.1ORCID,Corzana Francisco6ORCID,Jiménez-Osés Gonzalo27ORCID,Bernardes Gonçalo J. L.13ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom

2. Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160 Derio, Spain

3. Instituto de Medicina Molecular, João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal

4. Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland

5. Cambridge Centre for Proteomics, Gleeson Building, University of Cambridge, Tennis Court Road, CB2 1QR Cambridge, United Kingdom

6. Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, 26006 Logroño, Spain

7. Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain

Funder

AstraZeneca

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Ministerio de Ciencia e Innovaci?n

European Regional Development Fund

Carlsbergfondet

Biotechnology and Biological Sciences Research Council

Funda??o para a Ci?ncia e a Tecnologia

European Molecular Biology Organization

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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