Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical <i>S</i>-Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase-Reference-Cited by-同舟云学术

Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S-Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase

Published:2022-05-27 Issue:22 Volume:144 Page:9910-9919
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zhang Jiawei¹,Hou Xueli²³,Chen Zhang¹,Ko Yeonjin¹,Ruszczycky Mark W.⁴,Chen Yutian⁴,Zhou Jiahai³⁵,Liu Hung-wen¹⁴^ORCID

Affiliation:

1. Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States

2. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, China

3. State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

4. Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States

5. CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Funder

Welch Foundation

Science and Technology Commission of Shanghai Municipality

National Institute of General Medical Sciences

Chinese Academy of Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c02676

Reference51 articles.