Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing

Author:

Cheng Emmeline L.1,Cardle Ian I.12ORCID,Kacherovsky Nataly1,Bansia Harsh3,Wang Tong4ORCID,Zhou Yunshi1,Raman Jai1,Yen Albert1,Gutierrez Dominique35,Salipante Stephen J.6,des Georges Amédée378,Jensen Michael C.29,Pun Suzie H.1ORCID

Affiliation:

1. Department of Bioengineering, University of Washington, Seattle, Washington 98195-5061, United States

2. Seattle Children’s Therapeutics, Seattle, Washington 98101, United States

3. Structural Biology Initiative, CUNY Advanced Science Research Center, City University of New York, New York, New York 10031, United States

4. Nanoscience Initiative, CUNY Advanced Science Research Center, City University of New York, New York, New York 10031, United States

5. Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York (CUNY), New York, New York 10016, United States

6. Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195-7110, United States

7. Ph.D. Programs in Biochemistry and Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States

8. Department of Chemistry and Biochemistry, City College of New York, New York, New York 10031, United States

9. Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, United States

Funder

National Cancer Institute

Bristol-Myers Squibb

National Institute on Aging

National Institute of General Medical Sciences

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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