Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C

Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C–C Bond

Published:2022-09-06 Issue:37 Volume:144 Page:16715-16719
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zhu Yuxun¹,Shiraishi Taro¹^ORCID,Lin Jianwen¹,Inaba Keito¹,Ito Atsuro¹,Ogura Yusuke¹,Nishiyama Makoto¹^ORCID,Kuzuyama Tomohisa¹²^ORCID

Affiliation:

1. Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

2. Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

Funder

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c06546

Reference21 articles.

1. Phosphonate Biochemistry

2. Biosynthetic pathways and enzymes involved in the production of phosphonic acid natural products

3. Phosphonothrixin, a Novel Herbicidal Antibiotic Produced by Saccharothrix sp. ST-888. I. Taxonomy, Fermentation, Isolation and Biological Properties.

4. Isoprenoid Biosynthesis. Metabolite Profiling of Peppermint Oil Gland Secretory Cells and Application to Herbicide Target Analysis

5. Concise and scalable synthesis of (±)-phosphonothrixin

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