Benzylic Dehydroxylation of Echinocandin Antifungal Drugs Restores Efficacy against Resistance Conferred by Mutated Glucan Synthase-Reference-Cited by-同舟云学术

Benzylic Dehydroxylation of Echinocandin Antifungal Drugs Restores Efficacy against Resistance Conferred by Mutated Glucan Synthase

Published:2022-03-29 Issue:13 Volume:144 Page:5965-5975
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Logviniuk Dana¹^ORCID,Jaber Qais Z.¹^ORCID,Dobrovetsky Roman¹^ORCID,Kozer Noga²,Ksiezopolska Ewa³⁴,Gabaldón Toni³⁴⁵⁶,Carmeli Shmuel¹^ORCID,Fridman Micha¹^ORCID

Affiliation:

1. School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 6997801, Israel

2. The Wohl Drug Discovery institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 7610001, Israel

3. Barcelona Supercomputing Centre (BSC-CNS), Jordi Girona, 29, Barcelona 08034, Spain

4. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, Barcelona 08028, Spain

5. Catalan Institution for Research and Advanced Studies (ICREA), Passeig de Lluís Companys, 23, Barcelona 08010, Spain

6. Centro Investigación Biomédica En Red de Enfermedades Infecciosas, Madrid 28029, Spain

Funder

Israel Science Foundation

Ministerio de Ciencia e Innovaci?n

?la Caixa? Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c00269

Reference73 articles.

1. The Still Underestimated Problem of Fungal Diseases Worldwide

2. Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium

3. Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery

4. An insight into the antifungal pipeline: selected new molecules and beyond

5. Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

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