A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion-Reference-Cited by-同舟云学术

A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion

Published:2022-11-22 Issue:49 Volume:144 Page:22493-22504
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zhang Leran¹^ORCID,Lovell Scott²,De Vita Elena¹,Jagtap Pravin Kumar Ankush³⁴^ORCID,Lucy Daniel¹,Goya Grocin Andrea¹^ORCID,Kjær Svend⁵,Borg Annabel⁵,Hennig Janosch³⁴,Miller Aubry K.⁶,Tate Edward W.¹^ORCID

Affiliation:

1. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K.

2. Department of Life Sciences, University of Bath, Bath BA2 7AX, U.K.

3. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany

4. Chair of Biochemistry IV, Biophysical Chemistry, University of Bayreuth, Bayreuth 95447, Germany

5. Structural Biology Science Technology Platform, The Francis Crick Institute, London NW1 1AT, U.K.

6. Cancer Drug Development Group, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany

Funder

Engineering and Physical Sciences Research Council

Worldwide Cancer Research

H2020 Marie Sklodowska-Curie Actions

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c07378

Reference55 articles.

1. A completed KLK activome profile: investigation of activation profiles of KLK9, 10, and 15

2. Unleashing the therapeutic potential of human kallikrein-related serine proteases

3. Prostate-specific antigen (PSA) is activated by KLK2 in prostate cancer ex vivo models and in prostate-targeted PSA/KLK2 double transgenic mice

4. A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer

5. The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer

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