Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl

Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl–Cu Species

Published:2022-03-26 Issue:13 Volume:144 Page:5985-5995
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Dong Yuyang¹^ORCID,Schuppe Alexander W.¹^ORCID,Mai Binh Khanh²^ORCID,Liu Peng²^ORCID,Buchwald Stephen L.¹^ORCID

Affiliation:

1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

2. Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

Funder

Arnold and Mabel Beckman Foundation

National Institute of General Medical Sciences

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c00734

Reference75 articles.

1. Stereodivergent Construction of Tertiary Fluorides in Vicinal Stereogenic Pairs by Allylic Substitution with Iridium and Copper Catalysts

2. Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis

3. CuH-Catalyzed Enantioselective Ketone Allylation with 1,3-Dienes: Scope, Mechanism, and Applications

4. Engaging Aldehydes in CuH‐Catalyzed Reductive Coupling Reactions: Stereoselective Allylation with Unactivated 1,3‐Diene Pronucleophiles

5. A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes

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