Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization

Author:

Sahin Cagla12ORCID,Østerlund Eva Christina3,Österlund Nicklas4ORCID,Costeira-Paulo Joana5,Pedersen Jannik Nedergaard1,Christiansen Gunna6,Nielsen Janni1,Grønnemose Anne Louise13,Amstrup Søren Kirk12,Tiwari Manish K.7ORCID,Rao R. Shyama Prasad8ORCID,Bjerrum Morten Jannik7ORCID,Ilag Leopold L.9,Davies Michael J.10ORCID,Marklund Erik G.5ORCID,Pedersen Jan Skov111,Landreh Michael12ORCID,Møller Ian Max13,Jørgensen Thomas J. D.3ORCID,Otzen Daniel Erik12ORCID

Affiliation:

1. Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark

2. Department of Molecular Biology and Genetics, Aarhus University, Universitetsbyen 81, DK-8000 Aarhus C, Denmark

3. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

4. Department of Biochemistry and Biophysics, Stockholm University, SE-114 18 Stockholm, Sweden

5. Department of Chemistry - BMC, BMC − Uppsala University, Box 576, SE-751 23 Uppsala, Sweden

6. Department of Health Science and Technology, Medical Microbiology and Immunology, Aalborg University, Fredrik Bajers Vej 3b, DK-9220 Aalborg Ø, Denmark

7. Department Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark

8. Biostatistics and Bioinformatics Division, Yenepoya Research Center, Yenepoya University, Mangaluru-575018, Karnataka, India

9. Department of Materials and Environmental Chemistry, Stockholm University, SE-114 18 Stockholm, Sweden

10. Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark

11. Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark

12. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solnavägen 9, SE-171 65 Solna, Sweden

13. Department of Molecular Biology and Genetics, Aarhus University, Forsøgsvej 1, DK-4200 Slagelse, Denmark

Funder

Vetenskapsrådet

Det Frie Forskningsråd

Novo Nordisk Fonden

H2020 Marie Sklodowska-Curie Actions

Marie Sklodowska-Curie Actions

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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