Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile-Reference-Cited by-同舟云学术

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile

Published:2022-08-24 Issue:35 Volume:144 Page:15916-15921
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zhang Ziyang¹²^ORCID,Morstein Johannes¹^ORCID,Ecker Andrew K.¹^ORCID,Guiley Keelan Z.¹,Shokat Kevan M.¹^ORCID

Affiliation:

1. Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94158, United States

2. Department of Chemistry, University of California Berkeley, Berkeley, California 94720, United States

Funder

Howard Hughes Medical Institute

National Cancer Institute

Damon Runyon Cancer Research Foundation

Samuel Waxman Cancer Research Foundation

National Institute of General Medical Sciences

Mark Foundation For Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c05377

Reference39 articles.

1. RAS Proteins and Their Regulators in Human Disease

2. The Frequency of Ras Mutations in Cancer

3. Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

4. RAS-targeted therapies: is the undruggable drugged?

5. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

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