1. Center for Molecular Design and Preformulations, Toronto General Research Institute, Toronto General Hospital, Toronto, ON M5G 2C4 Canada, Department of Immunology, Departments of Pharmaceutical Sciences and Chemistry, and McLaughlin Center for Molecular Medicine, University of Toronto, Toronto, Ontario, Canada, and Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina 27412