Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors-Reference-Cited by-同舟云学术

Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Published:2013-06-13 Issue:12 Volume:56 Page:4921-4937
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zheng Xiaozhang¹,Bauer Paul¹,Baumeister Timm¹,Buckmelter Alexandre J.¹,Caligiuri Maureen¹,Clodfelter Karl H.¹,Han Bingsong¹,Ho Yen-Ching¹,Kley Nikolai¹,Lin Jian¹,Reynolds Dominic J.¹,Sharma Geeta¹,Smith Chase C.¹,Wang Zhongguo¹,Dragovich Peter S.²,Oh Angela²,Wang Weiru²,Zak Mark²,Gunzner-Toste Janet²,Zhao Guiling²,Yuen Po-wai³,Bair Kenneth W.¹

Affiliation:

1. Forma Therapeutics, Inc., 500 Arsenal Street, Watertown, Massachusetts 02472, United States

2. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

3. Pharmaron Beijing, Co. Ltd., 6 Tai He Road, BDA Beijing, 100176, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400186h

Reference39 articles.

1. The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells