1. Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan, Alfresa Pharma Co., 2-24-3, Sho, Ibaraki, Osaka 567-0806, Japan, and Department of Bioinformatics, Graduate School of Allied Health Sciences, Faculty of Medicine, Osaka University, Osaka 565-0871, Japan