Efficient Approaches to S-Alkyl-N-alkylisothioureas:  Syntheses of Histamine H3 Antagonist Clobenpropit and Its Analogues

Author:

Yoneyama Hiroki1,Shimoda Ayako1,Araki Lisa1,Hatano Kouta1,Sakamoto Yasuhiko1,Kurihara Takushi1,Yamatodani Atsushi1,Harusawa Shinya1

Affiliation:

1. Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan, Alfresa Pharma Co., 2-24-3, Sho, Ibaraki, Osaka 567-0806, Japan, and Department of Bioinformatics, Graduate School of Allied Health Sciences, Faculty of Medicine, Osaka University, Osaka 565-0871, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference47 articles.

1. (a) Sandler, R. S.; Karo, W.Organic Functional Group Preparations, 2nd ed.; Academic Press, Inc.  New York, 1986; pp 206−210.

2. (b) Smith, M. B.; March, J.March's Advanced Organic Chemistry, 5th ed.; John Wiley & Sons, Inc.  New York, 2001; pp 495−496.

3. Alkylation of ethylenethiourea with alcohols: a convenient synthesis of S-alkyl-isothioureas without toxic alkylating agents

4. Smiles-Type Rearrangement ofN-trans-Styrylsulfonyl) andN-(4-Phenyl-1,3-butadienylsulfonyl)thioureas and Isothioureas

5. Cycloaddition in synthesis of sulfonamide derivatives. I. A new method for preparation of N-(C-amino-alkylthiomethylene)benzenesulfonamide.

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