Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity-Reference-Cited by-同舟云学术

Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity

Published:2008-08-23 Issue:18 Volume:51 Page:5758-5765
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chao Esther Y.¹,Caravella Justin A.¹,Watson Mike A.¹,Campobasso Nino¹,Ghisletti Serena¹,Billin Andrew N.¹,Galardi Cristin¹,Wang Ping¹,Laffitte Bryan A.¹,Iannone Marie A.¹,Goodwin Bryan J.¹,Nichols Jason A.¹,Parks Derek J.¹,Stewart Eugene¹,Wiethe Robert W.¹,Williams Shawn P.¹,Smallwood Angela¹,Pearce Kenneth H.¹,Glass Christopher K.¹,Willson Timothy M.¹,Zuercher William J.¹,Collins Jon L.¹

Affiliation:

1. GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, and Departments of Cellular and Molecular Medicine and Medicine, School of Medicine, University of California, La Jolla, San Diego, California 92093

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800612u

Reference22 articles.

1. Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

2. 24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis.

3. Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines

4. Role of LXRs in control of lipogenesis

5. Liver X Receptor and Farnesoid X Receptor as Therapeutic Targets

Cited by 46 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Liver X receptors: From pharmacology to nanoparticle-based drug delivery;European Journal of Pharmacology;2023-10

2. Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB;Cellular and Molecular Life Sciences;2023-03-17

3. A structural perspective of liver X receptors;Vitamins and Hormones;2023

4. Dehydrocholesterol Reductase 24 (DHCR24): Medicinal Chemistry, Pharmacology and Novel Therapeutic Options;Current Medicinal Chemistry;2021-11-15

5. Nuclear Hormone Receptor Medicinal Chemistry;Burger's Medicinal Chemistry and Drug Discovery;2021-04-26