Design, Synthesis, and Structure–Activity Relationship Studies of Novel 3-Alkylindole Derivatives as Selective and Highly Potent Myeloperoxidase Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Structure–Activity Relationship Studies of Novel 3-Alkylindole Derivatives as Selective and Highly Potent Myeloperoxidase Inhibitors

Published:2013-05-06 Issue:10 Volume:56 Page:3943-3958
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Soubhye Jalal,Aldib Iyas,Elfving Betina¹,Gelbcke Michel,Furtmüller Paul G.²,Podrecca Manuel³,Conotte Raphaël³,Colet Jean-Marie³,Rousseau Alexandre⁴,Reye Florence,Sarakbi Ahmad,Vanhaeverbeek Michel⁴,Kauffmann Jean-Michel,Obinger Christian³,Nève Jean,Prévost Martine,Zouaoui Boudjeltia Karim⁴,Dufrasne Francois,Van Antwerpen Pierre

Affiliation:

1. Centre for Psychiatric Research, Aarhus University Hospital Risskov, 8240 Risskov, Denmark

2. Department of Chemistry, Division of Biochemistry at the Vienna Institute of BioTechnology, BOKU−University of Natural Resources and Life Sciences, Muthgasse 18, A-1190 Vienna

3. Department of Human Biology and Toxicology, Faculty of Medicine and Pharmacy, University of Mons, B7000 Mons, Belgium

4. Laboratory of Experimentral Medicine, CHU Charleroi, A. Vesale Hospital, and Université Libre de Bruxelles, 6110 Montigny-le-Tilleul, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4001538

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2. Studies on the chlorinating activity of myeloperoxidase.

3. Myeloperoxidase: friend and foe