Fragment-Based Lead Discovery and Design
Author:
Affiliation:
1. Infection Innovative Medicines Unit, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States
Publisher
American Chemical Society (ACS)
Subject
Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ci400731w
Reference124 articles.
1. Recent Progress in Understanding Activity Cliffs and Their Utility in Medicinal Chemistry
2. Anatomy of hot spots in protein interfaces
3. Cover Picture: From Activity Cliffs to Target-Specific Scoring Models and Pharmacophore Hypotheses (ChemMedChem 9/2011)
4. A computational procedure for determining energetically favorable binding sites on biologically important macromolecules
5. Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4
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