1. Contribution from the School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan, PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan, National Institute of Health Sciences (NIHS), Setagaya, Tokyo 158-8501, Japan, and Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511, Japan