Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-Oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-Induced Hepatotoxicity-Reference-Cited by-同舟云学术

Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-Oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-Induced Hepatotoxicity

Published:2009-03-03 Issue:4 Volume:22 Page:699-707
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Chen Chi¹,Krausz Kristopher W.¹,Shah Yatrik M.¹,Idle Jeffrey R.¹,Gonzalez Frank J.¹

Affiliation:

1. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892, and Institute of Pharmacology, First Faculty of Medicine, Charles University, Prague 12800, Czech Republic

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx800464q

Reference46 articles.

1. Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study

2. Genomics and Proteomics Analysis of Acetaminophen Toxicity in Mouse Liver

3. Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

4. LC-MS-Based Metabolomics in Drug Metabolism

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