1. Departments of Anesthesiology, Pharmacology and Therapeutics, and Cellular and Physiological Sciences, University of British Columbia, 2350 Health Science Mall, Vancouver, BC V6T 1Z3, Canada, and Department of Biochemistry and Molecular Pharmacology, Programs in Neuroscience and Chemical Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324