1. Contribution from the Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Presto, JST Agency, 4-8-1 Honcho, Kawaguchi, Saitama, 332-0012, Japan, and Graduate School of Engineering, Osaka University, CREST, JST Agency, Yamada-oka, Suita, Osaka 565-0871, Japan