Nucleoside Transport Inhibitors: Structure−Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α1-Acid Glycoprotein-Reference-Cited by-同舟云学术

Nucleoside Transport Inhibitors: Structure−Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α1-Acid Glycoprotein

Published:2011-03-02 Issue:6 Volume:54 Page:1847-1859
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Saravanan Kappusamy¹,Barlow Hannah C.¹,Barton Marion¹,Calvert A. Hilary²,Golding Bernard T.¹,Newell David R.²,Northen Julian S.¹,Curtin Nicola J.²,Thomas Huw D.²,Griffin Roger J.¹

Affiliation:

1. Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.

2. Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O’Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101493z

Reference40 articles.

1. The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms

2. Nucleoside transporters: from scavengers to novel therapeutic targets

3. Physiology of Nucleoside Transporters: Back to the Future. . . .

4. From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates

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