Investigation of Drug–Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy-Reference-Cited by-同舟云学术

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Investigation of Drug–Excipient Interactions in Lapatinib Amorphous Solid Dispersions Using Solid-State NMR Spectroscopy

Published:2015-01-28 Issue:3 Volume:12 Page:857-866
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Song Yang¹,Yang Xinghao²,Chen Xin³,Nie Haichen¹,Byrn Stephen¹,Lubach Joseph W.⁴

Affiliation:

1. Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States

2. College of Life Sciences, Nanjing Normal University, Nanjing 210046, P. R. China

3. GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States

4. Small Molecule Pharmaceutical Sciences, Genentech, Inc., South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp500692a

Reference30 articles.

1. Characteristics and Significance of the Amorphous State in Pharmaceutical Systems

2. Amorphous pharmaceutical solids: preparation, characterization and stabilization

3. Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25

4. Stabilization of Low Glass Transition Temperature Indomethacin Formulations: Impact of Polymer-Type and Its Concentration

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