Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)-Reference-Cited by-同舟云学术

Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)

Published:2007-01-20 Issue:4 Volume:50 Page:794-806
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sturino Claudio F.¹,O'Neill Gary¹,Lachance Nicolas¹,Boyd Michael¹,Berthelette Carl¹,Labelle Marc¹,Li Lianhai¹,Roy Bruno¹,Scheigetz John¹,Tsou Nancy¹,Aubin Yves¹,Bateman Kevin P.¹,Chauret Nathalie¹,Day Stephen H.¹,Lévesque Jean-François¹,Seto Carmai¹,Silva Jose H.¹,Trimble Laird A.¹,Carriere Marie-Claude¹,Denis Danielle¹,Greig Gillian¹,Kargman Stacia¹,Lamontagne Sonia¹,Mathieu Marie-Claude¹,Sawyer Nicole¹,Slipetz Deborah¹,Abraham William M.¹,Jones Tom¹,McAuliffe Malia¹,Piechuta Hana¹,Nicoll-Griffith Deborah A.¹,Wang Zhaoyin¹,Zamboni Robert¹,Young Robert N.¹,Metters Kathleen M.¹

Affiliation:

1. Department of Medicinal Chemistry, Merck Frosst Canada & Co., 16711 Trans Canada Highway, Kirkland, Quebec H9H 3L1, Canada, Department of Biochemistry, Merck Frosst Canada & Co., 16711 Trans Canada Highway, Kirkland, Quebec H9H 3L1, Canada, Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, New Jersey 07065, Miller School of Medicine, University of Miami at Mount Sinai Medical Center, 430 Alton Road, Miami Beach, Florida 33140, and Department of Pharmacology, Merck...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0603668

Reference38 articles.

1. Histamine and asthma: an appraisal based on specific H1-receptor antagonism

2. Mediators of allergic rhinitis

3. Effects of Thromboxane A₂ Receptor Antagonist (Bay u 3405) on Nasal Symptoms after Antigen Challenge in Sensitized Guinea Pigs

Cited by 169 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of 5,5′-Dinitro- and 5,5′-Diaminobis(cyclopenta[b]indoles) Bound at N4,N4′ Atoms with a Dioxoalkane Spacer;Журнал общей химии;2024-07-02

2. Visible-light-mediated sulfonylation of anilines with sulfonyl fluorides;Frontiers in Chemistry;2023-08-25

3. Indole-Based and Cyclopentenylindole-Based Analogues Containing Fluorine Group as Potential 18F-Labeled Positron Emission Tomography (PET) G-Protein Coupled Receptor 44 (GPR44) Tracers;Pharmaceuticals;2023-08-24

4. Synthesis of Cyclopenta[b]indoles via Sc(III)-Catalyzed Annulation of Vinyl Diazoacetates with Indole-Derived Unsaturated Imines;Organic Letters;2023-05-01

5. Regiodivergent synthesis of sulfone-tethered lactam–lactones bearing four contiguous stereocenters;RSC Advances;2023