Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)-Reference-Cited by-同舟云学术

Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)

Published:2007-01-20 Issue:4 Volume:50 Page:794-806
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sturino Claudio F.¹,O'Neill Gary¹,Lachance Nicolas¹,Boyd Michael¹,Berthelette Carl¹,Labelle Marc¹,Li Lianhai¹,Roy Bruno¹,Scheigetz John¹,Tsou Nancy¹,Aubin Yves¹,Bateman Kevin P.¹,Chauret Nathalie¹,Day Stephen H.¹,Lévesque Jean-François¹,Seto Carmai¹,Silva Jose H.¹,Trimble Laird A.¹,Carriere Marie-Claude¹,Denis Danielle¹,Greig Gillian¹,Kargman Stacia¹,Lamontagne Sonia¹,Mathieu Marie-Claude¹,Sawyer Nicole¹,Slipetz Deborah¹,Abraham William M.¹,Jones Tom¹,McAuliffe Malia¹,Piechuta Hana¹,Nicoll-Griffith Deborah A.¹,Wang Zhaoyin¹,Zamboni Robert¹,Young Robert N.¹,Metters Kathleen M.¹

Affiliation:

1. Department of Medicinal Chemistry, Merck Frosst Canada & Co., 16711 Trans Canada Highway, Kirkland, Quebec H9H 3L1, Canada, Department of Biochemistry, Merck Frosst Canada & Co., 16711 Trans Canada Highway, Kirkland, Quebec H9H 3L1, Canada, Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, New Jersey 07065, Miller School of Medicine, University of Miami at Mount Sinai Medical Center, 430 Alton Road, Miami Beach, Florida 33140, and Department of Pharmacology, Merck...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0603668

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