Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5-d]azepines as Potent 5-Hydroxytryptamine 2C (5-HT2C) Receptor Agonists with Exquisite Functional Selectivity over 5-HT2A and 5-HT2B Receptors-Reference-Cited by-同舟云学术

Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5-d]azepines as Potent 5-Hydroxytryptamine 2C (5-HT2C) Receptor Agonists with Exquisite Functional Selectivity over 5-HT2A and 5-HT2B Receptors

Published:2014-06-17 Issue:12 Volume:57 Page:5258-5269
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Storer R. Ian,Brennan Paul E.,Brown Alan D.,Bungay Peter J.,Conlon Kelly M.,Corbett Matthew S.¹,DePianta Robert P.¹,Fish Paul V.,Heifetz Alexander²,Ho Danny K. H.,Jessiman Alan S.,McMurray Gordon,de Oliveira Cesar Augusto F.¹,Roberts Lee R.,Root James A.,Shanmugasundaram Veerabahu¹,Shapiro Michael J.¹,Skerten Melanie,Westbrook Dominique,Wheeler Simon,Whitlock Gavin A.,Wright John

Affiliation:

1. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

2. Evotec (UK) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire, OX14 4RZ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5003292

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