1. Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, Department of Chemistry, University of Puerto Rico, Río Piedras Campus, San Juan, Puerto Rico 00934, Department of Biochemistry and Biophysics and Johnson Research Foundation, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6059, Department of Biochemistry and Molecular Biology, Dalhousie University, Nova Scotia, Canada B3H 4H7