Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol

Author:

Rashidian Azam1,Dušek Jan23,Drastik Martin4,Smutná Lucie2,Fritsche Kristin5,Braeuning Albert5,Pijnenburg Dirk6,van Beuningen Rinie6,Honkakoski Paavo7ORCID,Poso Antti1891011ORCID,Kronenberger Thales891011ORCID,Pavek Petr2

Affiliation:

1. Department of Internal Medicine VIII, University Hospital of Tübingen, Tübingen, Baden-Württemberg 72076, Germany

2. Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic

3. Department of Physiology, Faculty of Medicine in Hradec Kralove, Charles University, Šimkova 870, Hradec Králové 500 03, Czech Republic

4. Department of Biophysics and Physical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic

5. Department Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, Berlin 10589, Germany

6. PamGene International B.V., Wolvenhoek 10, ‘s-Hertogenbosch 5211HH, Netherlands

7. School of Pharmacy, University of Eastern Finland, Yliopistonranta 1 C, Kuopio 72011, Finland

8. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio 70211, Finland

9. Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard-Karls-Universität, Tübingen, Auf der Morgenstelle 8, Tübingen 72076, Germany

10. Tübingen Center for Academic Drug Discovery & Development (TüCAD2), Tübingen 72076, Germany

11. Excellence Cluster “Controlling Microbes to Fight Infections” (CMFI), Tübingen 72076, Germany

Funder

Bundesministerium f?r Bildung und Forschung

Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy

Grantov? Agentura Cesk? Republiky

H2020 Health

Ministerium f?r Wissenschaft, Forschung und Kunst Baden-W?rttemberg

Publisher

American Chemical Society (ACS)

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