A Population-Based Cohort Study of Respiratory Disease and Long-Term Exposure to Iron and Copper in Fine Particulate Air Pollution and Their Combined Impact on Reactive Oxygen Species Generation in Human Lungs

Author:

Zhang Zilong12ORCID,Weichenthal Scott34ORCID,Kwong Jeffrey C.1256,Burnett Richard T.7,Hatzopoulou Marianne8,Jerrett Michael9,van Donkelaar Aaron1011ORCID,Bai Li2,Martin Randall V.101112,Copes Ray15,Lu Hong2,Lakey Pascale13ORCID,Shiraiwa Manabu13ORCID,Chen Hong1257ORCID

Affiliation:

1. Public Health Ontario, Toronto, ON M5G 1V2, Canada

2. ICES, Toronto, ON M4N 3M5, Canada

3. Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC H3A 0G4, Canada

4. Air Health Science Division, Health Canada, Ottawa, ON K1A 0K9, Canada

5. Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada

6. Department of Family and Community Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada

7. Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada

8. Department of Civil and Mineral Engineering, University of Toronto, Toronto, ON ON M5S, Canada

9. School of Public Health, University of California Los Angeles, Los Angeles, California 90095, United States

10. Department of Physics and Atmospheric Science, Dalhousie University, Halifax, NS B3H 4R2, Canada

11. Department of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, United States

12. Harvard-Smithsonian Centre for Astrophysics, Cambridge, Massachusetts 02138, United States

13. Department of Chemistry, University of California Irvine, Irvine, California 92697, United States

Funder

Health Effects Institute

Health Canada

Ontario Ministry of Health and Long-Term Care

Public Health Ontario

Publisher

American Chemical Society (ACS)

Subject

Environmental Chemistry,General Chemistry

Reference64 articles.

1. World Health Organization. Global Health Estimates 2016: Deaths by Causes, Age, Sex, by Country and by Region, 2000–2016. 2018; https://www.who.int/healthinfo/global_burden_disease/estimates/en/index1.html.

2. Global Asthma Network. The Global Asthma Report 2018. http://www.globalasthmareport.org/.

3. Jacquemin, B.; Schikowski, T.; Carsin, A. E.; Hansell, A.; Krämer, U.; Sunyer, J.; Probst-Hensch, N.; Kauffmann, F.; Künzli, N.The role of air pollution in adult-onset asthma: a review of the current evidence Pubmed201233606619

4. Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis

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