Genomic Characterization Revealed PM2.5-Associated Mutational Signatures in Lung Cancer Including Activation of APOBEC3B

Author:

Fan Rongrong1ORCID,Xu Lin1ORCID,Cui Bowen2,Li Daochuan3,Sun Xueying1,Qi Yuan1,Rao Jianan2,Wang Kai4,Wang Cheng45,Zhao Kunming1,Zhao Yanjie1,Dai Juncheng45,Chen Wen3ORCID,Shen Hongbing46,Liu Yu278,Yu Dianke1ORCID

Affiliation:

1. School of Public Health, Qingdao University, 308 Ningxia Road, Qingdao 266071, China

2. Pediatric Translational Medicine Institute, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

3. Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China

4. Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China

5. Department of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China

6. Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine and China International Cooperation Center for Environment and Human Health, Genomic Science and Precision Medicine Institute, Gusu School, Nanjing Medical University, Nanjing 211166, China

7. Key Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

8. Fujian Children’s Hospital, Fujian Branch of Shanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Fuzhou 350000, China

Funder

National Natural Science Foundation of China

Shanghai Key Laboratory of Clinical Molecular Diagnostics for Pediatrics

Innovative research team of high-level local universities in Shanghai

Publisher

American Chemical Society (ACS)

Subject

Environmental Chemistry,General Chemistry

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