Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments

Author:

Agathokleous Evgenios12ORCID,Barceló Damià34ORCID,Aschner Michael5ORCID,Azevedo Ricardo Antunes6,Bhattacharya Prosun7ORCID,Costantini David8ORCID,Cutler G. Christopher9,De Marco Alessandra10ORCID,Docea Anca Oana11,Dórea José G.12,Duke Stephen O.13ORCID,Efferth Thomas14,Fatta-Kassinos Despo15,Fotopoulos Vasileios16ORCID,Ginebreda Antonio17,Guedes Raul Narciso C.18,Hayes A. Wallace1920,Iavicoli Ivo21ORCID,Kalantzi Olga-Ioanna22ORCID,Koike Takayoshi23,Kouretas Demetrios24,Kumar Manish25,Manautou José E.26,Moore Michael N.272829,Paoletti Elena30,Peñuelas Josep3132,Picó Yolanda33ORCID,Reiter Russel J.34,Rezaee Ramin3536,Rinklebe Jörg37ORCID,Rocha-Santos Teresa38,Sicard Pierre39,Sonne Christian4041ORCID,Teaf Christopher42,Tsatsakis Aristidis43,Vardavas Alexander I.43,Wang Wenjie4445,Zeng Eddy Y.46ORCID,Calabrese Edward J.47

Affiliation:

1. Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD), Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu China

2. Research Center for Global Changes and Ecosystem Carbon Sequestration & Mitigation, School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu China

3. Institute of Environmental Assessment and Water Research, IDAEA-CSIC; Barcelona 08034, Spain

4. Catalan Institute for Water Research, ICRA-CERCA; Girona 17003, Spain

5. Department of Molecular Pharmacology, Albert Einstein College of Medicine; Bronx, New York 10461, United States

6. Departamento de Genética, Escola Superior de Agricultura “Luiz de Queiroz”/Universidade de São Paulo (ESALQ/USP); São Paulo CEP 13418-900, Brazil

7. KTH-international Groundwater Arsenic Research Group, Department of Sustainable Development, Environmental Science and Engineering, KTH Royal Institute of Technology; Stockholm SE-100 44, Sweden

8. Unité Physiologie Moléculaire et Adaptation (PhyMA), UMR 7221 Muséum National d’Histoire Naturelle; CNRS, 7 Rue Cuvier, 75005 Paris, France

9. Department of Plant, Food, and Environmental Sciences, Agricultural Campus, Dalhousie University; Truro, Nova Scotia B2N 5E3, Canada

10. ENEA, CR Casaccia, SSPT-PVS; Rome 00123, Italy

11. Department of Toxicology, University of Medicine and Pharmacy of Craiova; Craiova 200349, Romania

12. Faculdade de Ciências da Saúde, Universidade de Brasília; Brasília 70919-970, Brazil

13. National Center for Natural Products Research, School of Pharmacy, University of Mississippi; Mississippi 38677, United States

14. Johannes Gutenberg University, Institute of Pharmaceutical and Biomedical Sciences, Department of Pharmaceutical Biology; Mainz 55128, Germany

15. Department of Civil and Environmental Engineering and Nireas-International Water Research Centre, School of Engineering, University of Cyprus; P.O. Box 20537, Nicosia 1678, Cyprus

16. Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology; Lemesos 3603, Cyprus

17. Environmental Chemistry, IDAEA-CSIC, c/Jordi Girona 18-26, Barcelona 08034, Spain

18. Departamento de Entomologia, Universidade Federal de Viçosa;Viçosa, Minas Gerais 36570-900, Brazil

19. Center for Environmental/Occupational Risk Analysis & Management, University of South Florida, College of Public Health; Tampa, Florida 33612, United States

20. Michigan State University; East Lansing, Michigan 48824, United States

21. Department of Public Health, Section of Occupational Medicine, University of Naples Federico II; Naples 80131, Italy

22. Department of Environment, University of the Aegean; Mytilene 81100, Greece

23. Research Faculty of Agriculture, Hokkaido University; Sapporo, Hokkaido 060-8589, Japan

24. Department of Biochemistry-Biotechnology, University of Thessaly, Larisa 41500, Greece

25. School of Engineering, University of Petroleum and Energy Studies; Dehradun 248007, India

26. Pharmaceutical Science, University of Connecticut, Storrs, Connecticut 06269, United States

27. European Centre for Environment & Human Health (ECEHH), University of Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital; Truro TR1 3HD, U.K.

28. Plymouth Marine Laboratory; Plymouth, Devon PL1 3DH, U.K.

29. School of Biological & Marine Sciences, University of Plymouth; Plymouth PL 4 8AA, U.K.

30. Institute of Research on Terrestrial Ecosystems, National Research Council; Sesto Fiorentino 50019, Italy

31. CSIC, Global Ecology Unit CREAF-CSIC-UAB; Bellaterra, Catalonia 08193, Spain

32. CREAF; Cerdanyola del Vallès, Catalonia 08193, Spain

33. Environmental and Food Safety Research Group (SAMA-UV), Desertification Research Centre (CIDE), Universitat de València-CSIC-GV; Valencia 46113, Spain

34. Department of Cell Systems and Anatomy, Joe R. and Teresa Lozano Long School of Medicine, UT Health San Antonio; San Antonio, Texas 78229, United States

35. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences,Mashhad 91779-43335, Iran

36. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 91779-43335, Iran

37. University of Wuppertal, School of Architecture and Civil Engineering, Institute of Foundation Engineering, Water, and Waste-Management, Laboratory of Soil, and Groundwater-Management; Wuppertal 42285, Germany

38. Centre for Environmental and Marine Studies (CESAM) & Department of Chemistry, University of Aveiro; Aveiro 3810-193, Portugal

39. ARGANS, 260 route du Pin Montard, Biot 06410, France

40. Aarhus University, Department of Bioscience, Arctic Research Centre (ARC); Roskilde DK-4000, Denmark

41. Henan Province Engineering Research Center for Biomass Value-added Products, School of Forestry, Henan Agricultural University; Zhengzhou 450002, China

42. Institute of Science & Public Affairs, Florida State University; Tallahassee, Florida 32306, United States

43. Laboratory of Toxicology, Medical School, University of Crete; Heraklion 71003, Greece

44. Key Laboratory of Forest Plant Ecology, Northeast Forestry University; Harbin 150040, China

45. Northeast Institute of Geography and Agroecology, Chinese Academy of Science; Changchun 130102, China

46. Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University; Guangzhou 511443, China

47. Department of Environmental Health Sciences, University of Massachusetts; Amherst, Massachusetts 01003, United States

Funder

ExxonMobil Foundation

Nanjing University of Information Science and Technology

Air Force Office of Scientific Research

Government of Jiangsu Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Environmental Chemistry,General Chemistry

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