Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways

Author:

Cheng Sibo Lucas12,Hedges Michael3ORCID,Keski-Rahkonen Pekka4,Chatziioannou Anastasia Chrysovalantou4,Scalbert Augustin4,Chung Kian Fan56ORCID,Sinharay Rudy57,Green David C.13,de Kok Theo M. C. M.8,Vlaanderen Jelle9,Kyrtopoulos Soterios A.10,Kelly Frank13,Portengen Lützen9,Vineis Paolo2ORCID,Vermeulen Roel C. H.911ORCID,Chadeau-Hyam Marc12ORCID,Dagnino Sonia212

Affiliation:

1. NIHR HPRU in Environmental Exposures and Health, Imperial College London, London W12 0BZ, U.K.

2. MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W12 7TA, U.K.

3. MRC Centre for Environment and Health, Environmental Research Group, Imperial College London, London W12 0BZ, U.K.

4. International Agency for Research on Cancer (IARC), Lyon 69366 Cedex, France

5. National Heart & Lung Institute, Imperial College London, London SW7 2AZ, U.K.

6. Royal Brompton & Harefield NHS Trust, London SW3 6NP, U.K.

7. Imperial College Healthcare NHS Trust, London W2 1NY, U.K.

8. Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht 6229 ER, The Netherlands

9. Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3584 CS, The Netherlands

10. National Hellenic Research Foundation, Athens 11635, Greece

11. Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht University, Utrecht 3584 CG, The Netherlands

12. Transporters in Imaging and Radiotherapy in Oncology (TIRO), School of Medicine, Direction de la Recherche Fondamentale (DRF), Institut des Sciences du Vivant Fréderic Joliot, Commissariat à l’Energie Atomique et aux Énergies Alternatives (CEA), Université Côte d’Azur (UniCA), Nice 06107, France

Funder

Imperial College London

British Heart Foundation

European Commission

Royal Brompton and Harefield NHS Foundation Trust

National Institute for Health Research Health Protection Research Unit

Publisher

American Chemical Society (ACS)

Reference61 articles.

1. Critical evaluation of the European diesel car boom - global comparison, environmental effects and various national strategies

2. Health Effects Institute Systematic Review and Meta-Analysis of Selected Health Effects of Long-Term Exposure to Traffic-Related Air Pollution 2022.

3. Greenbaum, D. S.; Cohen, A.; Samet, J. Sources of Air Pollution: Gasoline and Diesel Engines, Air Pollution and Cancer, IARC Scientific, 2018. https://www.iarc.who.int/wp-content/uploads/2018/07/AirPollutionandCancer161.pdf. (accessed July 28, 2023).

4. The Impact of Chronic Ambient Exposure to PM2.5 and Ozone on Asthma Prevalence and COPD Mortality Rates in the Southeastern United States

5. Evaluating the impact of long-term exposure to fine particulate matter on mortality among the elderly

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