Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid β-Oxidation Disorder, and Kidney Injury in a Manufactory in China

Author:

Lu Yao12,Gao Ke12,Li Xiaona3,Tang Zhi4,Xiang Li3,Zhao Hongzhi3,Fu Jianjie12ORCID,Wang Ling5,Zhu Nali6,Cai Zongwei3ORCID,Liang Yong5,Wang Yawei125ORCID,Jiang Guibin12ORCID

Affiliation:

1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

2. College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China

3. State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China

4. Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China

5. Institute of Environment and Health, Jianghan University, Wuhan 430056, China

6. Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Chinese Academy of Sciences

Sanming Project of Medicine in Shenzhen

Publisher

American Chemical Society (ACS)

Subject

Environmental Chemistry,General Chemistry

Reference47 articles.

1. POPRC. Listing of perfluorooctane sulfonic acid, its salts and perfluorooctane sulfonyl fluoride, 2009. http://chm.pops.int/Implementation/IndustrialPOPs/PFOS/Overview/tabid/5221/Default.aspx.

2. POPRC. Draft Risk Profile on Pentadecafluorooctanoic acid (PFOA, Perfluorooctanoic acid), its salts and PFOA-related compounds, 2016. http://chm.pops.int/TheConvention/POPsReviewCommittee/Meetings/POPRC11/POPRC11Followup/tabid/4723/Default.aspx.

3. POPRC. Draft risk profile on PFHxS, its salts and PFHxS-related compounds, 2018. http://chm.pops.int/TheConvention/POPsReviewCommittee/Meetings/POPRC13/POPRC13Followup/tabid/6173/Default.aspx.

4. Distribution of Perfluorooctane Sulfonate and Other Perfluorochemicals in the Ambient Environment around a Manufacturing Facility in China

5. Differential Accumulation and Elimination Behavior of Perfluoroalkyl Acid Isomers in Occupational Workers in a Manufactory in China

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