1. Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy, Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy, and Department of Veterinary Public Health and Animal Pathology, University of Bologna, Via Tolara di Sopra 30, 40064 Ozzano Emilia (BO), Italy