Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype-Reference-Cited by-同舟云学术

Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype

Published:2021-08-20 Issue:1 Volume:1 Page:21-30
ISSN:2694-2437
Container-title:ACS Bio & Med Chem Au
language:en
Short-container-title:ACS Bio Med Chem Au

Author:

Barbaro Lisa,Rodriguez Alice L.,Blevins Ashlyn N.^ORCID,Dickerson Jonathan W.,Billard Natasha,Boutaud Olivier,Rook Jerri L.,Niswender Colleen M.¹²,Conn P.Jeffrey³¹,Engers Darren W.,Lindsley Craig W.³^ORCID

Affiliation:

1. Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States,

2. Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232, United States

3. Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States,

Funder

William K. Warren Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsbiomedchemau.1c00024

Reference28 articles.

1. Mechanisms of signalling and biased agonism in G protein-coupled receptors

2. Structure and dynamics of GPCR signaling complexes

3. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

4. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

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