KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement-Reference-Cited by-同舟云学术

KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement

Published:2022-09-26 Issue:6 Volume:2 Page:617-626
ISSN:2694-2437
Container-title:ACS Bio & Med Chem Au
language:en
Short-container-title:ACS Bio Med Chem Au

Author:

Pagba Cynthia V.¹^ORCID,Gupta Amit K.¹,Naji Ali K.²,van der Hoeven Dharini²,Churion Kelly³,Liang Xiaowen¹^ORCID,Jakubec Jacob¹,Hook Magnus³,Zuo Yan¹,Martinez de Kraatz Marisela¹,Frost Jeffrey A.¹⁴,Gorfe Alemayehu A.¹⁵^ORCID

Affiliation:

1. Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, Texas 77030, United States

2. Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, 7500 Cambridge Street, Houston, Texas 77030, United States

3. Center for Infectious and Inflammatory Diseases, Texas A&M University Health Science Center, 2121 W Holcombe Blvd, Houston, Texas 77030, United States

4. Biochemistry and Cell Biology Program, UTHealth MD Anderson Cancer Center Graduate School of Biomedical Sciences, 6431 Fannin Street, Houston, Texas 77030, United States

5. Biochemistry and Cell Biology Program & Therapeutics and Pharmacology Program, UTHealth MD Anderson Cancer Center Graduate School of Biomedical Sciences, 6431 Fannin Street, Houston, Texas 77030, United States

Funder

U.S. Department of Defense

Cancer Prevention and Research Institute of Texas

Publisher

American Chemical Society (ACS)

Subject

Pharmaceutical Science,Drug Discovery,Molecular Biology,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsbiomedchemau.2c00045

Reference56 articles.

1. GEFs and GAPs: Critical Elements in the Control of Small G Proteins

2. RAS isoforms and mutations in cancer at a glance