The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism-Reference-Cited by-同舟云学术

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism

Published:2023-11-15 Issue:6 Volume:3 Page:528-541
ISSN:2694-2437
Container-title:ACS Bio & Med Chem Au
language:en
Short-container-title:ACS Bio Med Chem Au

Author:

Arutyunova Elena¹²^ORCID,Belovodskiy Alexandr³⁴,Chen Pu¹²,Khan Muhammad Bashir¹,Joyce Michael²⁴,Saffran Holly²⁴,Lu Jimmy¹²,Turner Zoe¹^ORCID,Bai Bing³⁴,Lamer Tess⁵^ORCID,Young Howard S.¹,Vederas John C.⁵^ORCID,Tyrrell D. Lorne²³⁴,Lemieux M. Joanne¹²^ORCID,Nieman James A.³⁴^ORCID

Affiliation:

1. Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada

2. Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada

3. Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada

4. Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada

5. Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada

Funder

Alberta Innovates

Striving for Pandemic Preparedness-Alberta Research Consortium SPP-ARC (Governemnt of Alberta)

CIHR, Government of Canada

GSK Chair in Virology

Publisher

American Chemical Society (ACS)

Subject

Pharmaceutical Science,Drug Discovery,Molecular Biology,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsbiomedchemau.3c00039

Reference63 articles.

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2. Current Strategies of Antiviral Drug Discovery for COVID-19

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4. An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

5. Metabolic Stability for Drug Discovery and Development

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