Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED

Author:

Richards Logan S.1,Flores Maria D.1,Millán Claudia2,Glynn Calina1,Zee Chih-Te1,Sawaya Michael R.3ORCID,Gallagher-Jones Marcus4,Borges Rafael J.2,Usón Isabel25,Rodriguez Jose A.1ORCID

Affiliation:

1. Department of Chemistry and Biochemistry; UCLA-DOE Institute for Genomics and Proteomics; STROBE, NSF Science and Technology Center, University of California, Los Angeles (UCLA), Los Angeles, California 90095, United States

2. Crystallographic Methods, Institute of Molecular Biology of Barcelona (IBMB−CSIC), Barcelona Science Park, Helix Building, Baldiri Reixach 15, 08028 Barcelona, Spain

3. Department of Biological Chemistry and Department of Chemistry and Biochemistry, University of California Los Angeles (UCLA), Howard Hughes Medical Institute (HHMI), UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, California 90095, United States

4. Correlated Imaging, The Rosalind Franklin Institute, Harwell Science & Innovation Campus, Rutherford Avenue, Harwell, Didcot OX11 0GD, United Kingdom

5. ICREA, Institució Catalana de Recerca i Estudis Avançats, Passeig Lluís Companys 23, 08003 Barcelona, Spain

Funder

University of California, Los Angeles

Ministerio de Ciencia e Innovaci?n

National Institute of Allergy and Infectious Diseases

David and Lucile Packard Foundation

Arnold and Mabel Beckman Foundation

Pew Charitable Trusts

Office of Science

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Generalitat de Catalunya

National Institute of General Medical Sciences

National Science Foundation

Division of Materials Research

Publisher

American Chemical Society (ACS)

Subject

Pharmaceutical Science,Drug Discovery,Molecular Biology,Biochemistry

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