N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as Potent and Selective Inhibitors of Glycogen Synthase Kinase 3 with Good Cellular Efficacy-Reference-Cited by-同舟云学术

N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as Potent and Selective Inhibitors of Glycogen Synthase Kinase 3 with Good Cellular Efficacy

Published:2004-08-13 Issue:19 Volume:47 Page:4716-4730
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tavares Francis X.¹,Boucheron Joyce A.¹,Dickerson Scott H.¹,Griffin Robert J.¹,Preugschat Frank¹,Thomson Stephen A.¹,Wang Tony Y.¹,Zhou Hui-Qiang¹

Affiliation:

1. Department of Medicinal Chemistry, Department of Metabolic Diseases, Department of Computational, Analytical and Structural Sciences, Department of Research Bioanalysis and Drug Metabolism, and Department of Biochemical and Analytical Pharmacology, GlaxoSmithKline, Research Triangle Park, North Carolina 27709

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm040063i

Reference79 articles.

1. Separation and Characterisation of Glycogen Synthase Kinase 3,Glycogen Synthase Kinase 4 and Glycogen Synthase Kinase 5 from Rabbit Skeletal Muscle

2. Biosynthesis of glycogen from uridine diphosphate glucose

3. Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism.

4. Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

5. GSK3 takes centre stage more than 20 years after its discovery

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