1. Sceptrin, an antimicrobial agent from the sponge Agelas sceptrum
2. Antiviral and antibacterial: ref 1 and Keifer, P. A.; Schwartz, R. E.; Koker, M. E. S.; Hughes, R. G.; Rittschof, D.; Rinehart, K. L.J. Org. Chem.1991,56, 2965−2975. Antihistiminic: Cafieri, F.; Carnuccio, R.; Fattorusso, E.; Taglialatela-Scafati, O.; Vallefuoco, T.Biorg. Med. Chem. Lett.1997,7, 2283−2288. Antimuscarinic: Rosa, R.; Silva, W.; de Motta, E.; Rodriguez, A. D.; Morales, J. J.; Ortiz, M.Experientia1992,48, 885−887. Sceptrin is the first and most potent nonpeptidic inhibitor of somatostatin and vasoactive intestinal peptide receptors: Vassas, A.; Bourdy, G.; Paillard, J. J.; Lavayre, J.; Pais, M.; Quirion, J. C.; Debitus, C.Planta Med.1996,62, 28−30. For additional reports of bioactivity, see ref 1.