Wortmannin-C20 Conjugates Generate Wortmannin-Reference-Cited by-同舟云学术

Wortmannin-C20 Conjugates Generate Wortmannin

Published:2005-12-22 Issue:2 Volume:49 Page:740-747
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yuan Hushan¹,Luo Ji¹,Weissleder Ralph¹,Cantley Lewis¹,Josephson Lee¹

Affiliation:

1. Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, and Department of Systems Biology, Harvard Medical School, and Division of Signal Transduction, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050699p

Reference39 articles.

1. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

2. Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

3. Phosphoinositide 3-Kinases as Targets for Therapeutic Intervention

4. Phosphoinositide 3-kinase γ: a key modulator in inflammation and allergy

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