Comprehensive Multidimensional Liquid Chromatography–Mass Spectrometry for the Characterization of Charge Variants of a Bispecific Antibody-Reference-Cited by-同舟云学术

Comprehensive Multidimensional Liquid Chromatography–Mass Spectrometry for the Characterization of Charge Variants of a Bispecific Antibody

Published:2022-11-28 Issue:12 Volume:33 Page:2319-2327
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Grunert Ingrid¹^ORCID,Heinrich Katrin¹,Hingar Michael¹,Ernst Juliane¹,Winter Martin¹,Bomans Katrin¹,Wagner Katharina¹,Fevre Arnaud²^ORCID,Reusch Dietmar¹,Wuhrer Manfred³^ORCID,Bulau Patrick²^ORCID

Affiliation:

1. Pharma Technical Development, Roche Diagnostics GmbH, 82377 Penzberg, Germany

2. Pharma Technical Development, Hoffmann-La Roche, 4070 Basel, Switzerland

3. Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 Leiden, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

https://pubs.acs.org/doi/pdf/10.1021/jasms.2c00296

Reference27 articles.

1. Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment

2. Bispecific human IgG by design

3. Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

4. ‘Knobs-into-holes’ engineering of antibody CH3 domains for heavy chain heterodimerization

5. Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

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