1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A2α: Effect of Substituents in Position 3 of the Indole Scaffold on Inhibitory Potency, Metabolic Stability, Solubility, and Bioavailability-Reference-Cited by-同舟云学术

1-(5-Carboxyindol-1-yl)propan-2-one Inhibitors of Human Cytosolic Phospholipase A2α: Effect of Substituents in Position 3 of the Indole Scaffold on Inhibitory Potency, Metabolic Stability, Solubility, and Bioavailability

Published:2010-11-10 Issue:23 Volume:53 Page:8298-8308
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bovens Stefanie¹,Schulze Elfringhoff Alwine¹,Kaptur Martina¹,Reinhardt Dirk²,Schäfers Michael²,Lehr Matthias¹

Affiliation:

1. Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Hittorfstrasse 58-62, 48149 Münster, Germany

2. European Institute for Molecular Imaging (EIMI), University of Münster, Mendelstrasse 11, 48149 Münster, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101094p

Reference43 articles.

1. Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s

2. Properties of the Group IV phospholipase A2 family

3. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2

4. Role of cytosolic phospholipase A2 in allergic response and parturition

5. Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2

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