Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach-Reference-Cited by-同舟云学术

Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach

Published:2005-10-29 Issue:24 Volume:48 Page:7829-7846
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hardcastle Ian R.¹,Cockcroft Xiaoling¹,Curtin Nicola J.¹,El-Murr Marine Desage¹,Leahy Justin J. J.¹,Stockley Martin¹,Golding Bernard T.¹,Rigoreau Laurent¹,Richardson Caroline¹,Smith Graeme C. M.¹,Griffin Roger J.¹

Affiliation:

1. Northern Institute for Cancer Research, School of Natural Sciences - Chemistry, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., KuDOS Pharmaceuticals Ltd., 327 Cambridge Science Park, Milton Road, Cambridge CB4 4WG, U.K., Northern Institute for Cancer Research, Medical School, Paul O'Gorman Building, Framlington Place, University of Newcastle upon Tyne, NE2 4HH, U.K., and KuDOS Horsham Ltd., Foundry Lane, Horsham, West Sussex RH13 5PX, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050444b

Reference27 articles.

2. The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Cited by 161 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development and therapeutic potential of DNA-dependent protein kinase inhibitors;Bioorganic Chemistry;2024-09

2. Cocaine-induced DNA-PK relieves RNAP II pausing by promoting TRIM28 phosphorylation;2024-08-19

3. -Proline catalyzed synthesis of biologically promising heterocycles under sustainable conditions;Tetrahedron Chem;2024-08

4. Identification of 6-Anilino Imidazo[4,5-c]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers;Journal of Medicinal Chemistry;2024-07-15

5. DNA-dependent protein kinase regulates cytosolic double-stranded DNA secretion from irradiated macrophages to increase radiosensitivity of tumors;Radiotherapy and Oncology;2024-04